15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15012 | Crolibulin | EPC2407 | Microtubule Associated |
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization. | |||
T2988 | (-)-Epigallocatechin Gallate | Epigallocatechol Gallate,EGCG | Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy |
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor... | |||
T1826 | PI3K-IN-1 | Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 | DNA-PK , PI3K |
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. | |||
T9901A-004 | Labetuzumab | IMMU-14,hMN-14,IMMU-100 | |
Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with anticancer activity that inhibits tumor growth and is used in the study of thyroid and colorectal cancer (CRC). | |||
T9111 | 8-Azaadenosine | Adenosine deaminase | |
8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells. | |||
T77075 | Spartalizumab | PDR001 | PD-1/PD-L1 |
Spartalizumab (PDR001) is a humanized immunoglobulin 4 monoclonal antibody that selectively binds to PD-1 at low concentrations and shows high activity. Spartalizumab blocks the interaction with PD-L1 and PD-L2, and can ... | |||
T36493 | CMLD-2 | Apoptosis , HuR | |
CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor ef... | |||
T39836 | Monoethyl phthalate | ||
Monoethyl phthalate is a metabolite of diethyl phthalate, serving as a urinary biomarker for phthalate exposure, and indicating potential risks of thyroid cancer and benign nodules. | |||
T70759 | CUDC-907 mesylate | ||
CUDC-907 mesylate is a small molecule inhibitor of histone deacetylase and PI3 kinase developed by Curis. It is investigated in clinical trials for the treatment of relapsed or refractory lymphomas, thyroid cancer, multi... | |||
T1656L | Vandetanib Fumarate | HSDB 8198,Zactima,Caprelsa,ZD 6474,Vandetanib | |
Vandetanib Fumarate is an orally available tyrosine kinase inhibitor. Vandetanib Fumarate works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epider... | |||
T60935 | H-Tyr-Phe-OH | ||
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) can be used as the biomarker to distinguish benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH is an orally active Angiotensin-converting enzyme inhibitor with t... | |||
T22552 | AD57 (hydrochloride) | Others | |
AD57, as polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer blocks the receptor tyrosine kinase RET in Drosophila (IC50: 2 nM). AD57 effectively suppresses tyrosine kinase ... | |||
T74893 | EGCG-4″-sulfate | ||
EGCG-4″-sulfate, a predominant polyphenol in green tea, demonstrates notable anticancer, antioxidant, and anti-inflammatory effects, particularly against colorectal cancer, myeloid leukemia, and thyroid carcinoma [1] [2]... | |||
T71267 | GNF-8625 | ||
GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in ... | |||
T63183 | RET-IN-9 | ||
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-channel transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, as well as in the mai... |